Histological Aspects in Lip Cancer

Major risk factor for lip cancer is smoking and alcohol consumption. The aim of the study was to reveal histopathological particularity in lip cancer correlated with smoking. Were studied medical records of patients admitted in Maxillo-Facial Clinic, Timisoara, between years 2003-2008, and were noted total number of patients and the number of patients with oral tumors, respectively with lip tumor. From the histological results were noted some aspects regarding keratinisation, differentiation degree, ulceration, the type of cellular infiltrate, tumor invasion, lymph node infiltration and tumor stadialization. Were studied 1013 patients, 744 males (73.44%) and 269 females 269 (26.56%), aged 24 and 85 years, with oral tumor surgically removed and histological diagnosed. Were selected 213 (30.86%) patients smokers and nonsmokers, with diagnostic scuamo-cellular carcinoma (SCC), localized on lip. Keratinisation frequency in lip SCC was 85% in smokers and non smokers. From investigated cases the most frequent differentiation degree was G2, independent of smoking, which reveals that smoking doesn’t influence histological differentiation. Tumor invasion was present in 1⁄4 of patients. Cellular inflammatory infiltrate was present in 1/3 of cases, with small differences depending of smoking. Most patients with lip tumor report to physician in stage I and II. Lip cancer incidence was increasing and was correlated with risk factor smoking. Were found increased frequency of keratinisation, cellular inflammatory infiltrate and invasion tendency in nearby tissues. Smoking cessation may decrease the risk of lip tumor formation.